JWH-018<\/a> (1-pentyl-3-(1-naphthoyl)indole, NA-PIMO[3] or AM-678) is a naphthoylindole-based analgesic that functions as a full agonist at both the CB1 and CB2 cannabinoid receptors, with modest selectivity for CB2. It has effects in animals that are comparable to those of tetrahydrocannabinol (THC), a cannabinoid found naturally in cannabis, which has led to its use in synthetic cannabis products sold legally in some countries as “incense blends”.<\/p>\n Buy JWH-018, Our online store<\/a> in USA sells JWH 018 powder. We offer several versions of the herbal mixture \u201cSpice\u201d. Due to the intoxicating properties of this synthetic cannabinoid, which are similar to those of 9-THC in cannabis, it is mostly consumed illegally. While jwh 018<\/a> is significantly more effective than similar cannabis dosages, it also presents significant challenges in identification using traditional 9-THC testing methods. In July 2009, JWH-018<\/a> was added to the U.S. Drug Enforcement Administration’s (DEA) list of drugs and chemicals of concern . In addition to reports of Spice seizures in Ohio and Florida, other states, including Alabama, Arkansas and Florida, have passed laws restricting the sale or possession of JWH-018 powder<\/a> .<\/a><\/p>\n JWH 018\u306f\u3001\u30a2\u30df\u30ce\u30a2\u30eb\u30ad\u30eb\u30a4\u30f3\u30c9\u30fc\u30ebWIN 55,212-2\u304b\u3089\u8abf\u88fd\u3055\u308c\u305f\u672b\u68a2\u6027\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9(CB2)\u53d7\u5bb9\u4f53\u306e\u4e2d\u7a0b\u5ea6\u306e\u9078\u629e\u7684\u30a2\u30b4\u30cb\u30b9\u30c8\u3067\u3042\u308b\u3002CB1\u304a\u3088\u3073CB2\u53d7\u5bb9\u4f53\u3078\u306e\u7d50\u5408Ki\u5024\u306f\u305d\u308c\u305e\u308c9.0\u304a\u3088\u30732.94 nM\u3067\u3042\u308a\u3001CB1:CB2\u6bd4\u306f3.061\u3067\u3042\u3063\u305f\u3002\u30e9\u30c3\u30c8\u3092\u7528\u3044\u305f\u8a66\u9a13\u306e\u7d50\u679c\u3001\u76f4\u8178\u6e29\u3001\u30c6\u30fc\u30eb\u30d5\u30ea\u30c3\u30af\u30a2\u30c3\u30bb\u30a4\u306b\u304a\u3051\u308b\u6700\u5927\u6297\u4fb5\u5bb3\u53d7\u5bb9\u4f5c\u7528\u3001\u81ea\u767a\u6d3b\u52d5\u306e\u6291\u5236\u3068\u3044\u3046\u70b9\u3067\u3001WIN 55,212-2\u3068\u540c\u7b49\u306e\u7d50\u679c\u304c\u5f97\u3089\u308c\u305f\u3002JWH 018 \u7c89\u672b\u3092\u7c73\u56fd\u3067\u30aa\u30f3\u30e9\u30a4\u30f3\u8ca9\u58f2\u3002 Narco Powders.<\/a><\/p>\n According to animal pharmacological studies, the pill JWH-018 has a similar effect to 9-THC. In mice it causes analgesia, a drop in body temperature, catalepsy and a general decrease in activity. By combining these four effects, scientists can predict psychoactivity in humans comparable to that of 9-THC. JWH-018’s<\/a> performance in all four tests suggests that it is likely to produce psychoactive effects in humans comparable to those of THC. In drug discrimination studies in rats, JWH-018 generalized to 9-THC and elicited subjective responses similar to those of 9-THC. JWH-018 binds to the cannabinoid receptor CB1 in the brain with greater affinity than 9-THC and exhibits agonistic properties in functional assays, suggesting that it may act similarly to 9-THC in vivo .<\/p>\n CB1\u53d7\u5bb9\u4f53\u306b\u304a\u3044\u3066\u4e0d\u5b8c\u5168\u306a\u4f5c\u52d5\u85ac\u3067\u3042\u308bTHC\u3068\u306f\u7570\u306a\u308a\u3001JWH-018\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u8cfc\u5165\u3084\u591a\u304f\u306e\u4eba\u5de5\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u306f\u5b8c\u5168\u306a\u4f5c\u52d5\u85ac\u3067\u3042\u308b\u3002THC\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u7d4c\u8def\u3092\u901a\u3058\u3066\u5927\u8133\u306eGABA\u53d7\u5bb9\u4f53\u306e\u795e\u7d4c\u4f1d\u9054\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002JWH-018\u306f\u3001THC\u3088\u308a\u3082\u9069\u5207\u306bGABA\u795e\u7d4c\u4f1d\u9054\u3092\u963b\u5bb3\u3059\u308b\u305f\u3081\u3001\u6975\u5ea6\u306e\u5026\u6020\u611f\u3001\u60aa\u5bd2\u3001\u307e\u308c\u306b\uff08\u4e3b\u306bJWH\u306e\u975e\u6a19\u6e96\u7684\u306a\u9867\u5ba2\u306b\u304a\u3044\u3066\uff09\u767a\u4f5c\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u3042\u308b\u3002\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u53d7\u5bb9\u4f53\u30d5\u30eb\u30a2\u30b4\u30cb\u30b9\u30c8\u306f\u3001\u904e\u5270\u306b\u4f7f\u7528\u3055\u308c\u305f\u5834\u5408\u3001\u9867\u5ba2\u306b\u73fe\u5b9f\u7684\u306a\u5371\u967a\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/p>\nJWH-018\u3092\u30aa\u30f3\u30e9\u30a4\u30f3\u3067\u8cfc\u5165\u3059\u308b<\/h3>\n
JWH-018\u306e\u8ca9\u58f2\uff5cJWH-018\u3092\u30aa\u30f3\u30e9\u30a4\u30f3\u3067\u6ce8\u6587\u3059\u308b<\/h3>\n
JWH-018\u306f\u6b27\u5dde\u3067\u5165\u624b\u53ef\u80fd<\/h3>\n
\u5408\u6210\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u306e\u8cfc\u5165<\/h3>\n