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Wat is JWH-018?

JWH-018 (1-pentyl-3-(1-naphthoyl)indole, NA-PIMO[3] or AM-678) is a naphthoylindole-based analgesic that functions as a full agonist at both the CB1 and CB2 cannabinoid receptors, with modest selectivity for CB2. It has effects in animals that are comparable to those of tetrahydrocannabinol (THC), a cannabinoid found naturally in cannabis, which has led to its use in synthetic cannabis products sold legally in some countries as “incense blends”.

JWH-018 online kopen

Buy JWH-018, Our online store in USA sells JWH 018 powder. We offer several versions of the herbal mixture “Spice”. Due to the intoxicating properties of this synthetic cannabinoid, which are similar to those of 9-THC in cannabis, it is mostly consumed illegally. While jwh 018 is significantly more effective than similar cannabis dosages, it also presents significant challenges in identification using traditional 9-THC testing methods. In July 2009, JWH-018 was added to the U.S. Drug Enforcement Administration’s (DEA) list of drugs and chemicals of concern . In addition to reports of Spice seizures in Ohio and Florida, other states, including Alabama, Arkansas and Florida, have passed laws restricting the sale or possession of JWH-018 powder .

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JWH 018, een matig selectieve agonist van de perifere cannabinoïde (CB2)-receptor, wordt bereid uit de aminoalkylindool WIN 55.212-2. De Ki waarden voor binding aan de CB1- en CB2-receptoren zijn respectievelijk 9,0 en 2,94 nM voor een CB1:CB2-verhouding van 3,061. De Ki waarden voor binding aan de CB1 en CB2 receptoren zijn respectievelijk 9,0 en 2,94 nM, voor een CB1:CB2 ratio van 3,061. Er werden ratten getest en de resultaten waren vergelijkbaar met die van WIN 55.212-2 wat betreft rectale temperatuur, maximaal antinociceptief effect in de tail flick assay en remming van spontane activiteit. JWH 018 poeder online verkopen in de VS. Narco Powders.

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According to animal pharmacological studies, the pill JWH-018 has a similar effect to 9-THC. In mice it causes analgesia, a drop in body temperature, catalepsy and a general decrease in activity. By combining these four effects, scientists can predict psychoactivity in humans comparable to that of 9-THC. JWH-018’s performance in all four tests suggests that it is likely to produce psychoactive effects in humans comparable to those of THC. In drug discrimination studies in rats, JWH-018 generalized to 9-THC and elicited subjective responses similar to those of 9-THC. JWH-018 binds to the cannabinoid receptor CB1 in the brain with greater affinity than 9-THC and exhibits agonistic properties in functional assays, suggesting that it may act similarly to 9-THC in vivo .

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In tegenstelling tot THC, dat een onvolledige agonist van CB1-receptoren is, zijn JWH-018 online kopen en vele andere cannabinoïden volledige agonisten. Het is aangetoond dat THC de neurotransmissie van GABA-receptoren in de kleine hersenen via verschillende wegen belemmert. JWH-018 kan extreme malaise, koude rillingen en in zeldzame gevallen (meestal bij niet-standaard JWH-klanten) epileptische aanvallen veroorzaken, omdat het de GABA-neurotransmissie beter remt dan THC. Cannabinoïde receptor full agonisten kunnen echte gevaren voor de cliënt opleveren bij overmatig gebruik.

Various physical and mental unfriendly effects have been noted while using JWH-018 purchased online. In one study, insane relapses and malaise were described as side effects in thoroughly treated patients with mental illnesses after inhaling JWH-018.[21] Due to concerns about the ability of JWH-018 and other manufactured cannabinoids to cause psychosis in vulnerable people, it has been suggested that individuals with risk factors for insanity (such as a past or family history of psychosis) should not use these substances.