在线购买 JWH-018

什么是 JWH-018？

JWH-018 (1-pentyl-3-(1-naphthoyl)indole, NA-PIMO[3] or AM-678) is a naphthoylindole-based analgesic that functions as a full agonist at both the CB1 and CB2 cannabinoid receptors, with modest selectivity for CB2. It has effects in animals that are comparable to those of tetrahydrocannabinol (THC), a cannabinoid found naturally in cannabis, which has led to its use in synthetic cannabis products sold legally in some countries as “incense blends”.

在线购买 JWH-018

Buy JWH-018, Our online store in USA sells JWH 018 powder. We offer several versions of the herbal mixture “Spice”. Due to the intoxicating properties of this synthetic cannabinoid, which are similar to those of 9-THC in cannabis, it is mostly consumed illegally. While jwh 018 is significantly more effective than similar cannabis dosages, it also presents significant challenges in identification using traditional 9-THC testing methods. In July 2009, JWH-018 was added to the U.S. Drug Enforcement Administration’s (DEA) list of drugs and chemicals of concern . In addition to reports of Spice seizures in Ohio and Florida, other states, including Alabama, Arkansas and Florida, have passed laws restricting the sale or possession of JWH-018 powder .

JWH-018 出售 | 在线订购 JWH-018

JWH 018 是一种中度选择性的外周大麻素（CB2）受体激动剂，由氨基烷基吲哚 WIN 55,212-2 制备而成。与 CB1 和 CB2 受体结合的 Ki 值分别为 9.0 和 2.94 nM，CB1:CB2 比率为 3.061。对大鼠进行了测试，在直肠温度、尾摇试验中的最大抗痛觉效应和抑制自发活动方面，测试结果与 WIN 55,212-2 相当。在美国网上销售 JWH 018 粉剂。 Narco Powders.

JWH-018 在欧洲上市

According to animal pharmacological studies, the pill JWH-018 has a similar effect to 9-THC. In mice it causes analgesia, a drop in body temperature, catalepsy and a general decrease in activity. By combining these four effects, scientists can predict psychoactivity in humans comparable to that of 9-THC. JWH-018’s performance in all four tests suggests that it is likely to produce psychoactive effects in humans comparable to those of THC. In drug discrimination studies in rats, JWH-018 generalized to 9-THC and elicited subjective responses similar to those of 9-THC. JWH-018 binds to the cannabinoid receptor CB1 in the brain with greater affinity than 9-THC and exhibits agonistic properties in functional assays, suggesting that it may act similarly to 9-THC in vivo .

购买合成大麻素

四氢大麻酚是 CB1 受体的不完全激动剂，而在线购买的 JWH-018 和许多经过改造的大麻素则是完全激动剂。事实证明，四氢大麻酚会通过多种途径阻碍大脑中 GABA 受体的神经传递。JWH-018 可引起极度不适、寒战，在极少数情况下（主要是非标准 JWH 客户）还会导致癫痫发作，因为它对 GABA 神经传递的抑制作用比四氢大麻酚更强。如果过量使用大麻素受体完全激动剂，会给客户带来真正的危险。

Various physical and mental unfriendly effects have been noted while using JWH-018 purchased online. In one study, insane relapses and malaise were described as side effects in thoroughly treated patients with mental illnesses after inhaling JWH-018.[21] Due to concerns about the ability of JWH-018 and other manufactured cannabinoids to cause psychosis in vulnerable people, it has been suggested that individuals with risk factors for insanity (such as a past or family history of psychosis) should not use these substances.