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Qu'est-ce que le JWH-018 ?

JWH-018 (1-pentyl-3-(1-naphthoyl)indole, NA-PIMO[3] or AM-678) is a naphthoylindole-based analgesic that functions as a full agonist at both the CB1 and CB2 cannabinoid receptors, with modest selectivity for CB2. It has effects in animals that are comparable to those of tetrahydrocannabinol (THC), a cannabinoid found naturally in cannabis, which has led to its use in synthetic cannabis products sold legally in some countries as “incense blends”.

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Buy JWH-018, Our online store in USA sells JWH 018 powder. We offer several versions of the herbal mixture “Spice”. Due to the intoxicating properties of this synthetic cannabinoid, which are similar to those of 9-THC in cannabis, it is mostly consumed illegally. While jwh 018 is significantly more effective than similar cannabis dosages, it also presents significant challenges in identification using traditional 9-THC testing methods. In July 2009, JWH-018 was added to the U.S. Drug Enforcement Administration’s (DEA) list of drugs and chemicals of concern . In addition to reports of Spice seizures in Ohio and Florida, other states, including Alabama, Arkansas and Florida, have passed laws restricting the sale or possession of JWH-018 powder .

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Le JWH 018, un agoniste modérément sélectif du récepteur cannabinoïde périphérique (CB2), est préparé à partir de l'aminoalkylindole WIN 55 212-2. Les valeurs Ki pour la liaison aux récepteurs CB1 et CB2 sont respectivement de 9,0 et 2,94 nM, pour un rapport CB1:CB2 de 3,061. Des rats ont été testés et les résultats étaient comparables à ceux du WIN 55,212-2 en termes de température rectale, d'effet antinociceptif maximal dans le test de la queue et d'inhibition de l'activité spontanée. Vente en ligne de la poudre JWH 018 aux États-Unis. Narco Powders.

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According to animal pharmacological studies, the pill JWH-018 has a similar effect to 9-THC. In mice it causes analgesia, a drop in body temperature, catalepsy and a general decrease in activity. By combining these four effects, scientists can predict psychoactivity in humans comparable to that of 9-THC. JWH-018’s performance in all four tests suggests that it is likely to produce psychoactive effects in humans comparable to those of THC. In drug discrimination studies in rats, JWH-018 generalized to 9-THC and elicited subjective responses similar to those of 9-THC. JWH-018 binds to the cannabinoid receptor CB1 in the brain with greater affinity than 9-THC and exhibits agonistic properties in functional assays, suggesting that it may act similarly to 9-THC in vivo .

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Contrairement au THC, qui est un agoniste incomplet des récepteurs CB1, le JWH-018 et de nombreux autres cannabinoïdes sont des agonistes complets. Il a été démontré que le THC entrave la neurotransmission des récepteurs GABA dans le cerveau par plusieurs voies. Le JWH-018 peut provoquer des malaises extrêmes, des frissons et, dans de rares cas (principalement chez les clients de JWH non standard), des crises d'épilepsie parce qu'il inhibe la neurotransmission GABA de manière plus adéquate que le THC. Les agonistes complets des récepteurs cannabinoïdes peuvent présenter de réels dangers pour le client s'ils sont utilisés de manière excessive.

Various physical and mental unfriendly effects have been noted while using JWH-018 purchased online. In one study, insane relapses and malaise were described as side effects in thoroughly treated patients with mental illnesses after inhaling JWH-018.[21] Due to concerns about the ability of JWH-018 and other manufactured cannabinoids to cause psychosis in vulnerable people, it has been suggested that individuals with risk factors for insanity (such as a past or family history of psychosis) should not use these substances.