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O que é o JWH-018?

JWH-018 (1-pentyl-3-(1-naphthoyl)indole, NA-PIMO[3] or AM-678) is a naphthoylindole-based analgesic that functions as a full agonist at both the CB1 and CB2 cannabinoid receptors, with modest selectivity for CB2. It has effects in animals that are comparable to those of tetrahydrocannabinol (THC), a cannabinoid found naturally in cannabis, which has led to its use in synthetic cannabis products sold legally in some countries as “incense blends”.

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Buy JWH-018, Our online store in USA sells JWH 018 powder. We offer several versions of the herbal mixture “Spice”. Due to the intoxicating properties of this synthetic cannabinoid, which are similar to those of 9-THC in cannabis, it is mostly consumed illegally. While jwh 018 is significantly more effective than similar cannabis dosages, it also presents significant challenges in identification using traditional 9-THC testing methods. In July 2009, JWH-018 was added to the U.S. Drug Enforcement Administration’s (DEA) list of drugs and chemicals of concern . In addition to reports of Spice seizures in Ohio and Florida, other states, including Alabama, Arkansas and Florida, have passed laws restricting the sale or possession of JWH-018 powder .

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O JWH 018, um agonista moderadamente seletivo do recetor canabinóide periférico (CB2), é preparado a partir do aminoalquilindole WIN 55,212-2. Os valores Ki para a ligação aos receptores CB1 e CB2 são 9,0 e 2,94 nM, respetivamente, para um rácio CB1:CB2 de 3,061. Os ratos foram testados e os resultados foram comparáveis aos do WIN 55,212-2 em termos de temperatura rectal, efeito antinociceptivo máximo no ensaio de movimento da cauda e inibição da atividade espontânea. Venda online do pó JWH 018 nos EUA. Narco Powders.

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According to animal pharmacological studies, the pill JWH-018 has a similar effect to 9-THC. In mice it causes analgesia, a drop in body temperature, catalepsy and a general decrease in activity. By combining these four effects, scientists can predict psychoactivity in humans comparable to that of 9-THC. JWH-018’s performance in all four tests suggests that it is likely to produce psychoactive effects in humans comparable to those of THC. In drug discrimination studies in rats, JWH-018 generalized to 9-THC and elicited subjective responses similar to those of 9-THC. JWH-018 binds to the cannabinoid receptor CB1 in the brain with greater affinity than 9-THC and exhibits agonistic properties in functional assays, suggesting that it may act similarly to 9-THC in vivo .

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Ao contrário do THC, que é um agonista incompleto dos receptores CB1, o purchase JWH-018 online, e numerosos canabinóides artificiais, são agonistas completos. Foi demonstrado que o THC impede a neurotransmissão do recetor GABA no cérebro através de várias vias. O JWH-018 pode causar mal-estar extremo, calafrios e, em casos raros (principalmente em clientes não padronizados do JWH), convulsões, porque inibe a neurotransmissão GABA mais adequadamente do que o THC. Os agonistas completos dos receptores canabinóides podem representar um perigo real para o cliente se forem utilizados em excesso.

Various physical and mental unfriendly effects have been noted while using JWH-018 purchased online. In one study, insane relapses and malaise were described as side effects in thoroughly treated patients with mental illnesses after inhaling JWH-018.[21] Due to concerns about the ability of JWH-018 and other manufactured cannabinoids to cause psychosis in vulnerable people, it has been suggested that individuals with risk factors for insanity (such as a past or family history of psychosis) should not use these substances.